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HIV/AIDS, immunosuppression in solid organ transplants). Neonatal herpes simplex is a HSV infection in an infant.It is a rare but serious condition, usually caused by vertical transmission of HSV-1 or -2) from mother to newborn.Symptoms may include painful swallowing (odynophagia) and difficulty swallowing (dysphagia).

When infecting the brain, the virus shows a preference for the temporal lobe.It can occur more than a week before or after a symptomatic recurrence in 50% of cases.Some individuals may have much lower patterns of shedding, but evidence supporting this is not fully verified; no significant differences are seen in the frequency of asymptomatic shedding when comparing persons with one to 12 annual recurrences to those with no recurrences.Individuals who participate in contact sports such as wrestling, rugby, and football(soccer), sometimes acquire a condition caused by HSV-1 known as herpes gladiatorum, scrumpox, wrestler's herpes, or mat herpes, which presents as skin ulceration on the face, ears, and neck.Symptoms include fever, headache, sore throat, and swollen glands. A herpetic infection of the brain thought to be caused by the transmission of virus from a peripheral site on the face following HSV-1 reactivation, along the trigeminal nerve axon, to the brain.

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